NSCLC is a heterogeneous disease with an increasing number of actionable and emerging biomarkers. Greater understanding of the heterogeneity of NSCLC has driven personalized approaches to patient management.4
new patients with the KRAS G12C mutation are diagnosed with NSCLC in the US5
with non-squamous NSCLC, second only to the prevalence of all EGFR mutations1
of all NSCLC patients receive testing for multiple actionable biomarkers6
AACR, American Association for Cancer Research; ALK, anaplastic lymphoma kinase; BRAF, proto-oncogene B-Raf; EGFR, epidermal growth factor receptor; ERBB2, erb-B2 receptor tyrosine kinase 2; HER2, human epidermal growth factor receptor 2; KEAP1, kelch-like ECH-associated protein; KRAS, Kirsten rat sarcoma; MET, mesenchymal-to-epithelial transition; NCCN, National Comprehensive Cancer Network; NSCLC, non-small cell lung cancer; NTRK, neurotrophic tyrosine receptor kinase; PD-L1, programmed cell death ligand 1; RET, rearranged during transfection; ROS1, c-ros oncogene 1; STK11, serine/threonine kinase 11; TMB, tumor mutational burden.
References: 1. Data on file, Amgen; [Analysis of AACR Genie v8]. 2. Riess JW, et al. J Thorac Oncol. 2018;13:1560-1568. 3. American Cancer Society. https://www.cancer.org/cancer/lung-cancer/treating-non-small-cell/targeted-therapies.html. Accessed September 9, 2021. 4. Pennell NA, et al. Am Soc Clin Oncol Educ Book. 2019;39:531-542. 5. Mullard A. Nat Rev Drug Discov. 2019;18:887-891. 6. Nadler E, et al. Presented at: The American Society of Clinical Oncology Annual Meeting; June 2021; Virtual Congress. 7. McGranahan N, et al. Sci Transl Med. 2015;7:283ra54. 8. Skoulidis F, et al. Nat Rev Cancer. 2019;19:495-509. 9. Spira A, et al. Lung Cancer. 2021;159:1-9. 10. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Non-Small Cell Lung Cancer v.6.2021. © National Comprehensive Cancer Network, Inc. 2021. All rights reserved. Accessed September 30, 2021. To view the most recent and complete version of the guideline, go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.